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1.025
Q1(Year 2015)
ISSN : 1026-3098
e-ISSN : 2345-3605
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Publication Information : Volume 23 - Number 1 - Successive Number 1
Type : Article
Topics of Paper : Transaction on Mechanical Engineering
English Title : A Computational Model for Estimation of Mechanical Parameters in Chemotactic Endothelial Cells
English Abstract : A cell migration numerical simulation is presented to mimic the motility of endothelial cells subjected to the concentration gradients of Forebrain embryonic cortical neuron conditioned medium (CM). This factor was previously shown to induce the directional chemotaxis of endothelial cells with over-expressed G protein coupled receptor 124 (GPR 124). A cell simulator program incorporates basic elements of the cell cytoskeleton including membrane, nucleus and cytoskeletons. The developed 2D cell model is capable of responding to concentration gradients of biochemical factors by changing the cytoskeleton arrangement. Random walk force, cell drag force and the cell inertial effects are also implemented into the cell migration to complete the simulation of the phenomenon.  The obtained results of cell migration were calibrated with experimental cell chemotaxis data. This model can be implemented for prediction of cell behavior during cell chemotaxis and also it provides a powerful tool to explain the cell migration phenomenon mechanistically.
English Keywords : Cell motility, chemotaxis, reaction-diffusion model, cell cytoeskeleton simulation
Refrences :
Number Of Pages :
From 260 to 267


Authors :
The AuthorAuthor SequenceOrganizationOrganization ( english )AffiliationEmailEducation
Amir Kiyoumarsioskouei 1Mechanical Engineering School, Sharif University of Technology, Tehran, Iran    
Dr. Amir Shamloo
(Author)
2Mechanical Engineering School, Sharif University of Technology, Tehran, Iran Assistant Professorshamloo@sharif.edu 
Sajjad Azimi 3Mechanical Engineering School, Sharif University of Technology, Tehran, Iran    
Mohammad Abeddoust 4Mechanical Engineering School, Sharif University of Technology, Tehran, Iran    
Prof. Mohammad Said Saidi 5Mechanical Engineering School, Sharif University of Technology, Tehran, Iran Professor  
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