Impact Factor :
1.025
Q1(Year 2015)
ISSN : 1026-3098
e-ISSN : 2345-3605
View Paper Details
Download Link :
( 536 Visit ) ( 42 Download )
Publication Information : Volume 23 - Number 2 - Successive Number 2
Type : Article
Topics of Paper : Transaction on Mechanical Engineering
English Title : An Alternative Mechanism for the formation of High Density Lipoprotein in Peripheral Tissues
English Abstract : High Density Lipoprotein (HDL) is a lipid-protein complex which is responsible to transport cholesterol and triglyceride molecules due to the inability of these compounds to dissolve in aqueous environment such as bloodstream. Among renowned probable structures, belt like structure is the most common shape which is proposed to this vital bimolecular complex. In this structure, the protein scaffold encompasses the lipid bilayer and a planar circular structure is formed. Several HDL simulations with embedded components in lipid section were performed. Here we applied a series of molecular dynamics simulations using MARTINI coarse grain force field to investigate an HDL model with pore of different radiuses in bilayer section instead of embedding components. The results of such studies revealed the probable structural modes in HDL configurations. In addition, totally 2.5 µs simulations lead to study the ratio of lipids to protein in HDL conformation and determine the structural shape of HDL and stability of each model due to atomic interactions. Furthermore, we proposed new conformation for HDL in its initial steps of constructing outside of cells and in peripheral tissues.
English Keywords : High Density Lipoprotein; Structural modes; Lipid protein complex; Assembly
Refrences :
Number Of Pages :
From 600 to 608


Authors :
The AuthorAuthor SequenceOrganizationOrganization ( english )AffiliationEmailEducation
B. Damirchi
(Author)
1Department of Mechanical Engineering, Sharif University of Technology, Tehran, Iran     
Prof. M. S. Saidi 2Department of Mechanical Engineering, Sharif University of Technology, Tehran, Iran  Professormssaidi@sharif.edu 
M. Rismanian 3Department of Mechanical Engineering, Sharif University of Technology, Tehran, Iran     
Dr. M. Amininasab 4Department of Cell and Molecular Biology, Faculty of Science, University of Tehran, Tehran, Iran Assistant Professor  
Published Issues
2017
Transactions on Civil Engineering
Transactions on Mechanical Engineering
Transactions on Industrial Engineering
2016
2015
Transactions on Civil Engineering
Transactions on Mechanical Engineering
Transactions on Chemistry and Chemical Engineering
Transactions on Computer Science & Engineering and Electrical Engineering
Transactions on Industrial Engineering
Transactions on Nanotechnology
2014
Transactions on Civil Engineering
Transactions on Mechanical Engineering
Transactions on Chemistry and Chemical Engineering
Transactions on Computer Science & Engineering and Electrical Engineering
Transactions on Industrial Engineering
Transactions on Nanotechnology
2013
Transactions on Civil Engineering
Transactions on Mechanical Engineering
Transactions on Chemistry and Chemical Engineering
Transactions on Computer Science & Engineering and Electrical Engineering
Transactions on Industrial Engineering
Transactions on Nanotechnology

Scientia Iranica All Rights Reserved.
© 2014 - Journal Management System. Powered by ADAK Co